منابع مشابه
Peptide antimicrobial agents.
Antimicrobial host defense peptides are produced by all complex organisms as well as some microbes and have diverse and complex antimicrobial activities. Collectively these peptides demonstrate a broad range of antiviral and antibacterial activities and modes of action, and it is important to distinguish between direct microbicidal and indirect activities against such pathogens. The structural ...
متن کاملAntiendotoxin activity of cationic peptide antimicrobial agents.
The endotoxin from gram-negative bacteria consists of a molecule lipopolysaccharide (LPS) which can be shed by bacteria during antimicrobial therapy. A resulting syndrome, endotoxic shock, is a leading cause of death in the developed world. Thus, there is great interest in the development of antimicrobial agents which can reverse rather than promote sepsis, especially given the recent disappoin...
متن کاملAntimicrobial Agents
Use of substances with antimicrobial properties is known to have been common practice for at least 2000 years. Ancient Egyptians and ancient Greeks used specific molds and plant extracts to treat infection. More recently, microbiologists such as Louis Pasteur and Jules Francois Joubert observed antagonism for some bacteria and discussed the merits of controlling these interactions in medicine. ...
متن کاملAntimicrobial Agents
INTRODUCTION................................................................. 13 PRECLINICAL TESTING STAGES ................................................................. 13 Discovery of New Antibiotics ................................................................. 13 Establishment of SAR ................................................................. 15 Animal Models for Studying the P...
متن کاملAntimicrobial agents.
The pharmacokinetics of apalcillin and piperacillin, each administered intravenously as a single 2-g dose, were compared in 10 volunteers in a randomized study of crossover design using bioassay and high-pressure liquid chromatographic procedures. The concentrations of both penicillins in serum were determined over a period of 12 h and in urine over 24 h. Concentrations of apalcillin and pipera...
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ژورنال
عنوان ژورنال: Clinical Microbiology Reviews
سال: 2006
ISSN: 0893-8512,1098-6618
DOI: 10.1128/cmr.00056-05